Inspired on Wired Magazine look, Clean News is a theme with a large content area, but it also has a wide sidebar that allows to display even a 300px width ad.
Home and single sidebars are independent, both widgetized, so you can easily choose what and where to display.
A lot of white space to make your content stand out, low weight and no plugins required. It will load in the blink of an eye.
Seo optimized, content loads first and titles use h1 tags on single pages.
Valid XHTML and CSS, as usual.
Released under GPL License.